career opportunities at pulmatrix

Pulmatrix is looking for individuals with the skills and talents that will most effectively contribute to our mission of advancing novel therapeutics that have significant potential to transform how we address respiratory diseases.

We are a committed and energetic team, at work and at play! Our culture affords us enjoyment and appreciation for each other, while providing a strong support network and respectful work environment.

Pulmatrix is an Equal Opportunity Employer, and offers a comprehensive benefits package, including health, dental, and life insurance, paid vacation and a 401(k) investment plan.


Career Opportunities Currently Available:
Sr. Research Associate
Analytical Development

 
At Pulmatrix, we are developing innovative inhaled therapies to address serious pulmonary disease using our clinically validated, proprietary iSPERSE technology. Leveraging the unique capabilities of iSPERSE to dramatically advance inhalation technology, we can create new therapies to improve patient outcomes.

Our pipeline of inhaled therapies represents innovative, first-in-class products. Our proprietary pipeline of novel therapies for respiratory diseases is led by PUR1900, PUR1800 and PUR5700. PUR1900 is an inhaled anti-infective to treat ABPA in severe asthmatics and cystic fibrosis patients. PUR1800 and PUR5700 are novel inhaled anti-inflammatory compounds that selectively inhibit kinases involved in inflammation. PUR1800 is being developed to treat and prevent exacerbations in patients with chronic obstructive pulmonary disease (COPD) and PUR5700 is being explored as a therapy for COPD, asthma and IPF. Our pipeline in major pulmonary diseases developed in collaboration with partners is led by PUR0200, a branded generic in clinical development for COPD.

iSPERSE is a, dry powder technology developed, patented and validated by Pulmatrix scientists and engineers to improve how drugs are directed into the lungs. iSPERSE products are designed to maximize local drug concentrations and reduce systemic side effects, in order to make possible a new generation of inhaled therapies to improve patient outcomes.

Overall Responsibility:
We are seeking an exceptional senior research associate to be a key member of the Analytical Development group. This position will lead the development and implementation of a range of analytic testing methods for the characterization of our solid-based inhalation dosage formulations for use in early stage clinical trials. The ideal candidate will possess a demonstrated expertise in analytical characterization of APIs (small and/or large molecules and drug products). Further, the candidate will be expected to apply strong organizational and communication skills to assist with method development, preparation of testing protocols and performing analyses to help drive the advancement of our product development programs.

Responsibilities:
  • Provide Analytical Development support in collaboration with cross-functional teams:
    • Perform UPLC/HPLC method development for assay and impurity profile characterization of drug substances and drug products.
    • Execute analysis of formulation development stability study test articles by HPLC, KF and other wet chemistry techniques
    • Contribute to scientific discussions to advance analytical development for characterization of drug product formulations
  • Assist in the management of analytic activities at external CRO/CMOs in order to plan, align and meet objectives and program deliverables.
  • Generate and execute protocols, write reports and initiate and/or implement changes to controlled documents including organization of analytic data for internal presentations and regulatory filings
  • Maintenance and operation of specialized equipment
  • Compliance with safety guidelines and good laboratory practices which includes but is not limited to working with potent drugs, the maintenance of laboratory documentation and following written procedures.
Skills:
  • Experience with UPLC/HPLC, KF, UV and wet chemistry method development and the execution of these techniques
  • Strong technical laboratory skills, knowledge of operation of chromatographic instrumentation, mobile phase preparation and experience in preparation of samples and standards. Experience in working with potent drugs is a plus.
  • Familiarity with chromatographic data systems including, but not limited to Waters Empower
  • Excellent documentation, strong oral and written communication skills
  • Strong attention to detail and demonstrated ability to be self-motivated and execute work independently as a contributor to a dynamic interdisciplinary R&D team
  • Excellent problem solving and data analysis skills with the ability to quickly learn and apply new concepts, techniques and practices
  • Knowledge of aerosol testing by cascade impaction or laser diffraction is a plus
Education & Experience:
  • BS/BA in Analytical Chemistry, Chemistry, Bioanalytical Chemistry or related fields
  • 3-5 years of relevant industry experience in biotech/pharmaceutical R&D; AD or QC

Contact: jobs@pulmatrix.com with cover letter and CV

CMC Project Manager
Pharmaceutical Development

 
At Pulmatrix, we are developing innovative inhaled therapies to address serious pulmonary disease using our clinically validated, proprietary iSPERSE technology. Leveraging the unique capabilities of iSPERSE to dramatically advance inhalation technology, we can create new therapies to improve patient outcomes.

Our pipeline of inhaled therapies represents innovative, first-in-class products. Our proprietary pipeline of novel therapies for respiratory diseases is led by PUR1900, PUR1800 and PUR5700. PUR1900 is an inhaled anti-infective to treat ABPA in severe asthmatics and cystic fibrosis patients. PUR1800 and PUR5700 are novel inhaled anti-inflammatory compounds that selectively inhibit kinases involved in inflammation. PUR1800 is being developed to treat and prevent exacerbations in patients with chronic obstructive pulmonary disease (COPD) and PUR5700 is being explored as a therapy for COPD, asthma and IPF. Our pipeline in major pulmonary diseases developed in collaboration with partners is led by PUR0200, a branded generic in clinical development for COPD.

iSPERSE is a, dry powder technology developed, patented and validated by Pulmatrix scientists and engineers to improve how drugs are directed into the lungs. iSPERSE products are designed to maximize local drug concentrations and reduce systemic side effects, in order to make possible a new generation of inhaled therapies to improve patient outcomes.

Overall Responsibility:
We are seeking a highly motivated, experienced CMC Project Manager to drive the advancement of the pharmaceutical development programs at Pulmatrix. This position will report to the head of CMC and will work closely across functional areas on product development teams, as well as manage external contractors. The work is highly collaborative and requires excellent communication skills and the ability to be part of a team. The successful candidate must have pharmaceutical product development knowledge to contribute to our CMC strategy for novel pulmonary formulations, and have a proven ability to meet technology research and development goals within aggressive timelines.

Responsibilities:
  • Provide basic project management support for CMC project teams including developing detailed project plans, project status and timelines.
  • Organize, schedule and coordinate CMC meetings and meetings with different vendors, CMOs and CROs under the leadership of a project leader.
  • Work with CMC team members representing analytical development, formulation development, process development and quality to facilitate the execution and completion of deliverables within the assigned timeframe.
  • Publish meetings agendas, manage data and assist in generating meeting minutes, action items and reports.
  • Manage shipment of API, intermediates and drug product to and from suppliers and contract manufacturing sites.
  • Assist in regulatory filings
  • Other responsibilities might be assigned.
Skills:
  • Reliable, self-motivated individual with positive attitude
  • Team-oriented with ability to work with junior and senior staff
  • Dedication to documentation and strong attention to detail
  • Strong oral and written communication skills, with the ability to prepare and present information to internal and external working teams
  • Ability to effectively manage time and prioritize tasks to meet tight timelines and shifting priorities in a fast-paced environment
  • Familiarity with pharmaceutical cGMP manufacturing experience is a plus
  • Familiarity with inhalation product development is a plus
Education & Experience:
  • Bachelor’s degree in a relevant field
  • 5+ years of experience in CMC drug development in the pharmaceutical industry
  • Proficiency in MS Project and other PM tools. PMP certificate is desirable.

Contact: jobs@pulmatrix.com with cover letter and CV

Development Engineer I
Pharmaceutical Development

 
At Pulmatrix, we are developing innovative inhaled therapies to address serious pulmonary disease using our clinically validated, proprietary iSPERSE technology. Leveraging the unique capabilities of iSPERSE to dramatically advance inhalation technology, we can create new therapies to improve patient outcomes.

Our pipeline of inhaled therapies represents innovative, first-in-class products. Our proprietary pipeline of novel therapies for respiratory diseases is led by PUR1900, PUR1800 and PUR5700. PUR1900 is an inhaled anti-infective to treat ABPA in severe asthmatics and cystic fibrosis patients. PUR1800 and PUR5700 are novel inhaled anti-inflammatory compounds that selectively inhibit kinases involved in inflammation. PUR1800 is being developed to treat and prevent exacerbations in patients with chronic obstructive pulmonary disease (COPD) and PUR5700 is being explored as a therapy for COPD, asthma and IPF. Our pipeline in major pulmonary diseases developed in collaboration with partners is led by PUR0200, a branded generic in clinical development for COPD.

iSPERSE is a, dry powder technology developed, patented and validated by Pulmatrix scientists and engineers to improve how drugs are directed into the lungs. iSPERSE products are designed to maximize local drug concentrations and reduce systemic side effects, in order to make possible a new generation of inhaled therapies to improve patient outcomes.

Overall Responsibility:
We are seeking a highly motivated, experienced senior scientist or engineer to join the Pharmaceutical Development group to provide technical leadership and hands-on performance in support of Pulmatrix development programs. This position will be a lead member of the Process Development group, which is responsible for developing engineered-particle production and filling processes at pilot and commercial scales. This position will work closely across functional areas on product development teams, as well as manage external contractors. The work is highly collaborative and requires excellent communication skills and the ability to be part of a team. The successful candidate must have pharmaceutical product development knowledge to contribute to our CMC strategy for novel pulmonary formulations, and have a proven ability to meet technology research and development goals within aggressive timelines. The ideal candidate will have expertise in process development of engineered particles and aerosols for pulmonary drug delivery.

Responsibilities:
  • Developing pharmaceutical manufacturing processes
  • Provide key technical direction for specific aspects of drug product development
  • Participate in multi-functional drug product development teams
  • Design, conduct, evaluate and interpret scientific studies to drive the development and understanding of our dry powder technology platform and lead drug development programs
  • Work closely and coordinate cross-functionally with formulation, solid-state, analytical and aerosol scientists and process engineers to develop robust formulations and processes in support of development projects
  • Assist in the management and troubleshooting of manufacturing operations at contract sites, including directing product development studies and reviewing batch production records
  • Author protocols, pharmaceutical development reports, SOPs, and other scientific/technical documents, which may support regulatory filings
  • Present study results to Formulation and Process Development team and summaries to cross-functional project teams
  • Participate in the development of the Pulmatrix intellectual property portfolio
  • Maintain a comprehensive understanding and review of pertinent scientific literature and industry initiatives
  • Possibility of managing daily activities of junior research associates and scientists or engineers to achieve team goals
Skills:
  • Command of physics, chemistry, and engineering principles
  • Exceptional scientific, technical, and problem-solving skills with the ability to design experiments and interpret data independently
  • Strong working knowledge of statistical analysis tools, in particular experimental design and interpretation of complex data sets
  • Knowledge of process development for the production of pharmaceutical products
  • Experience with process technology transfer to contract manufacturing organizations
  • Excellent technical laboratory skills
  • Reliable, self-motivated individual with positive attitude
  • Team-oriented with ability to work with junior and senior staff
  • Dedication to documentation and strong attention to detail
  • Strong oral and written communication skills, with the ability to prepare and present data to internal and external working teams
  • Ability to effectively manage time and prioritize tasks to meet tight timelines and shifting priorities in a fast-paced environment
  • Pharmaceutical cGMP manufacturing experience is a plus
  • Experience with particle engineering for pharmaceuticals, especially pulmonary drug delivery and interpretation of aerosol, solid-state and chemical analyses is a plus
  • Experience with pharmaceutical solids handling technology and processes, especially powder filling technology, is a plus
  • Experience working across scales, and direct scale-up experience, is a plus
  • Formal training in experimental statistics, and demonstrable competence in the scientific method, is a plus
  • Desire for continued training and growth opportunities, including willingness to learn new skills and contribute outside of specific area of expertise
Education & Experience:
  • Minimum of a Bachelor’s degree in Chemical Engineering, Materials Science/Engineering, Pharmaceutical Sciences or a related field and 5+ years of relevant industry experience in biotech/pharmaceutical R&D OR a M.Sc. with 4+ years of relevant experience OR a Ph.D. with a minimum of 2+ years of relevant experience.
  • A combination of experience and education will be taken into consideration for position and title.
  • Extensive experience in successful process development leadership and problem solving
  • Thorough operational understanding of regulatory requirements and industry standards for development of high quality development programs, including quality by design principles and risk analysis tools
  • Ability to work in a pilot lab and/or commercial facility that handles active pharmaceutical ingredients
  • Will require domestic and international travel, up to 15% of time
  • Must be authorized to work in the United States for any employer without the need for sponsorship

Contact: jobs@pulmatrix.com with cover letter and CV

Engineering Associate // Senior Engineering Associate
Pharmaceutical Development

 
At Pulmatrix, we are developing innovative inhaled therapies to address serious pulmonary disease using our clinically validated, proprietary iSPERSE technology. Leveraging the unique capabilities of iSPERSE to dramatically advance inhalation technology, we can create new therapies to improve patient outcomes.

Our pipeline of inhaled therapies represents innovative, first-in-class products. Our proprietary pipeline of novel therapies for respiratory diseases is led by PUR1900, PUR1800 and PUR5700. PUR1900 is an inhaled anti-infective to treat ABPA in severe asthmatics and cystic fibrosis patients. PUR1800 and PUR5700 are novel inhaled anti-inflammatory compounds that selectively inhibit kinases involved in inflammation. PUR1800 is being developed to treat and prevent exacerbations in patients with chronic obstructive pulmonary disease (COPD) and PUR5700 is being explored as a therapy for COPD, asthma and IPF. Our pipeline in major pulmonary diseases developed in collaboration with partners is led by PUR0200, a branded generic in clinical development for COPD.

iSPERSE is a, dry powder technology developed, patented and validated by Pulmatrix scientists and engineers to improve how drugs are directed into the lungs. iSPERSE products are designed to maximize local drug concentrations and reduce systemic side effects, in order to make possible a new generation of inhaled therapies to improve patient outcomes.

Overall Responsibility:
We are seeking a highly motivated engineer to join the Pharmaceutical Development group supporting process development for respiratory drug products.

Responsibilities:
  • Support development and optimization of engineered particle inhaled dosage forms. Specific methods may include bench and pilot-scale spray drying
  • Support development of new technologies
  • Perform physicochemical property and aerosol performance characterization of solid-based inhalation dosage forms
  • Support batch manufacture for development, pre-clinical and clinical studies
Skills:
  • Strong engineering fundamentals
  • Excellent problem solving and data analysis skills
  • Excellent oral and written communication skills
  • Attention to detail
  • Fluency in MS Office software
  • Accuracy in following instructions, generating data, and documenting data and procedures
  • Experience with general laboratory procedures
  • Demonstrated mechanical and/or electronics aptitude, or previous experience with pilot labs or hands-on controls engineering, is a plus
  • Familiarity/experience with particle engineering and/or spray drying is a plus
Education & Experience:
  • BS/BA or MS in Chemical Engineering, Biomedical Engineering, or related field
  • 1-5 years of experience in biotech/pharmaceutical R&D

Contact: jobs@pulmatrix.com with cover letter and CV



 
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